5-MTHF ES provides 17,000 mcg of 5-MTHF (5-methyltetrahydrofolate) per serving. 5-MTHF is the most biologically active form of the water-soluble B vitamin, folate;  and it may be the preferred form for those with variations in digestion, absorption, or folate metabolism. Data suggest that in comparison to synthetic folic acid, 5-MTHF increases plasma folate more effectively. In this formula, 5-MTHF is provided as Quatrefolic—the glucosamine salt of 5-MTHF. Quatrefolic has demonstrated excellent stability, solubility, and bioavailability compared to calcium salt forms of 5-MTHF.*

*Follow recommended dosing or use as directed by your healthcare practitioner. Individuals taking medication should discuss potential interactions with their healthcare practitioner prior to use. These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.